RISEK 20mg Caps 2x7s

Caps

Rs. 245.00

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Quick overview

Omeprazole 20mg

Omeprazole is a an oral antiulcer agent. Omeprazole is characterized as a gastric acid pump inhibitor because it blocks the final step of gastric acid production. It has a long duration of action and is very potent, allowing for once-daily administration. Despite its potency, it must be used in combination with antibiotics to be effective against Helicobacter pylori. Due to concern regarding long-term use, it was originally approved by the FDA in September 1989 for acute treatment only. In December 1994, an FDA advisory committee recommended it be approved for maintenance therapy of healed erosive esophagitis. In April 1996, it was approved for the treatment of H. pylori-associated duodenal ulcer. Belongs to a new class of antisecretory agents, the substituted benzimidazoles, which suppress gastric acid secretion by inhibiting the H+/K+ ATPase enzyme system of parietal cells. it, following activation in an acidic pH, binds irreversibly to the H+/K+ ATPase pump on the secretory surface of the parietal cell membrane. Subsequently, the secretion of hydrogen ions into the gastric lumen is inhibited. it inhibits both basal and stimulus-induced acid secretion.

Pack Price : Rs. 245.00
Description

Omeprazole 20mg

CHARACTERSTICS

Omeprazole also known as Proton pump Inhibitor. . It is of Synthetic origin and belongs to Benzimidazol. It belongs to H/K Atpase proton pump inhibitor pharmacological group on the basis of mechanism of action and also classified in Antacids pharmacological group.The Molecular Weight of Omeprazole is 345.40. Its pKa is 4.0, 8.7.

INDICATIONS

Omeprazole is primarily indicated in conditions like Acid reflux disease (long-term management), Benign gastric and duodenal ulceration, Benign gastric and duodenal ulcers, Benign gastric ulcer associated with H.pylori, Duodenal errosions, Duodenal or benign gastric ulcer associated with H.pylori, Duodenal ulcer, Duodenal ulcer associated with h. Pylori, Gastric acid reduction during anaesthesia, Gastric acid reduction during general anaesthesia, Gastric ulcer, Gastro-esophageal reflux disease, Gastro-oesophageal reflux disease, Gastro-oesophageal reflux disease (refractory to other treatment), Maintenance of recurrent duodenal ulcers, Non-ulcer dyspepsia, NSAID-associated gastric and duodenal ulcers, NSAID-associated gastric and duodenal ulcers (prophylaxis), NSAID-associated gastric and duodenal ulcers and duodenal errosions, NSAID-associated gastric or duodenal ulcers, NSAID-associated gastric or duodenal ulcers (prophylaxis), Prevention of relapse in duodenal ulcer, Prophylaxis for NSAID-associated gastric and duodenal ulcers, Prophylaxis of acid aspiration, Reflux oesophagitis, Resistant ulcers, Severe or recurrent duodenal and gastric ulcertion, Zollinger-ellison syndrome, and can also be given in adjunctive therapy as an alternative drug of choice in Acid aspiration syndrome prevention, GI bleeding.

INTERACTIONS

Omeprazole is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlprazolamCeftibutenCilostazoleClarithromycinomeperzole is used in combination with clarithromycin to treat patients with ulcer by helicobacter pylori.ClobazamClopidogrelCyanocobalaminomeperzole decrease the absorption of CyanocobalamineDiazepamomeperzole decrease the clearance of diazepamDigoxinOmeprazole may inhibit the absorption of digoxinMinorMonitor serum digoxin levels.EscitalopramHalazepamHydroxocobalaminLansoprazoleLodoxamide TromethamineMethotrexateOmeprazole increases the serum concentration of methotrexate by inhibiting its active tubular secretion through renal H+/K+ ATPase pumps.ModerateOmeprazole therapy should discontinue several days before administration of methotrexate. Closely monitor the serum level and toxicity of methotrexate. Use H2 antagonist as an alternative.NelfinavirPhenytoin (Na)omeperzole decrease the clearance of phenytoinRiluzoleOmeprazole could increase the rate of riluzole elimination. Sodium DiatrizoateShould not be use concurrently without informing doctor.TheophyllineOmeprazole may inhibit the absorption of theophyllineTocilizumabToclizumab increases the exposure of OmeprazoleVORICONAZOLEVoriconazole increases the effect and toxicity of omeprazoleWarfarin (Na)omeperzole decrease the clearance of warfarin These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

CONTRAINDICATIONS

Omeprazole

EFFECTS

The severe or irreversible adverse effects of Omeprazole, which give rise to further complications include Interstitial nephritis.Omeprazole produces potentially life-threatening effects which include Anaphylaxis. which are responsible for the discontinuation of Omeprazole therapy.The signs and symptoms that are produced after the acute overdosage of Omeprazole include Tachycardia, Drowsiness, Headache.The symptomatic adverse reactions produced by Omeprazole are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Dizziness, Headache, Fatigue, Nausea, Diarrhea, Myalgia, Constipation, Insomnia, Abdominal pain, Dry mouth, Urticaria, Pruritus, Photosensitivity, Skin rash, Impotence, Depression, Arthralgia, Myopathy, Gynecomastia, Agitation, Dry mouth, dizziness.

RISK

Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

WARNINING

Omeprazole should be used with caution in patients with liver or kidney disease. It should be used only when clearly needed during pregnancy. Avoid use during lactation. In elderly these is no problem in clinical use to data.

STORAGE

Caps Store Below 40�C. Protect from Sunlight and Moisture.

Dosage

Adult

Dose Single Frequency Route Instruction
20 to 40 mg 30 (30) 24 hourly PO For 4 weeks.
Description

Reviews

naveed Kandohi
Monday 31st August 2020 05:22:28 PM

Ggg


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