PANADOL EXTRA Tabs 100s

Tabs

Rs. 165.88

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Quick overview

Caffeine 1mg/ml

Caffeine is a mild CNS stimulant. It increases the alertness and is useful in staying awake. Caffeine is a 1,3,7-trimethylxanthine. its major sources are beverages (tea, cocoa and coffee). Caffeine is probably the most widely used social drug worldwide. Caffeine is used in combination to relieve vascular headaches. Caffeine is used paraenterally for the treatment of respiratory depression.

Paracetamol 1mg/ml

Paracetamol is analgesic and antipyretic agent. Paracetamol is the active metabolite of phenacetin, responsible for its analgesic effect. Paracetamol is a weak prostaglandin inhibitor in peripheral tissues and possesses no significant antinflammatory effects. Paracetamol is one of the most important drug used for the treatment of mild to moderate pain when an antinfalmmatory effect is not necessary. Paracetamol is preferred over aspirin as an analgesic/antipyretic for patients in whom aspirin is contraindicated, such as those who have a history of gastric ulcer or a coagulation disorder.

Pack Price : Rs. 165.88
Description

Caffeine 1mg/ml

CHARACTERSTICS

Caffeine also known as Methyl Theobromine, Methyl Theobromine, Methyl Theobromine. . It is of Natural origin and belongs to Xanthine. It belongs to Phosphodiesterase inhibitor pharmacological group on the basis of mechanism of action and also classified in CNS Stimulant pharmacological group.The Molecular Weight of Caffeine is 194.20. Its pKa is 13.9.

INDICATIONS

Caffeine is primarily indicated in conditions like Apnoea of prematurity, CNS stimulation, Headache, Migraine, and can also be given in adjunctive therapy as an alternative drug of choice in Asthma, Lumbar puncture headache.

INTERACTIONS

Caffeine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholCimetidine (HCl)CinoxacinCiprofloxacinCoadministration inhibit the metabolism of caffeine thus increasing its plasma concentration and pharmacological effect.Ciprofloxacin increases caffeine AUC by 50% to over 100% and reduces its clearance upto 50%.ModerateCaffeine intake should be avoided during treatment that may increase the risk of adverse effects like tremor,insomnia,tachycardia and blood pressure.DiazepamDipyridamoleDisulfiramDue to inhibition of caffeine metabolism in liver microsomes its concentration may be increases in cardiovascular and CNS .MinorCaffeine intake should be limited while taking disulfiram.EnoxacinFenoterol Use of Fenoterol with caffeine may increase risk of hypokalemia. Frusemide or FurosemideIron SaltsLevonorgestrelMexiletineNimodipineNorfloxacinPentobarbitone (Na)Phenytoin (Na)Pipemidic AcidRiluzoleCaffeine could decrease the rate of riluzole elimination. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

CONTRAINDICATIONS

Caffeine is contraindicated in conditions like Cardiac arrhythmia,Peptic ulcer.

EFFECTS

The severe or irreversible adverse effects of Caffeine, which give rise to further complications include Tachycardia, Caffeinism, Irregular fever, Insomnia, Anorexia, Anxiety, Irritability, CNS stimulation, Diuresis, Tachycardia.Caffeine produces potentially life-threatening effects which include Tinnitus, Nausea, Vomiting, Tachycardia, Hypersensitivity, Restlessness, Agitation, Anxiety, Diuresis, Palpitation, Shock, Urticaria, Hyperglycemia. which are responsible for the discontinuation of Caffeine therapy.The signs and symptoms that are produced after the acute overdosage of Caffeine include Tachycardia, Emesis, Diuresis, CNS stimulation, Metabolic acidosis, Ketosis, Hyperglycemia, Acetonuria.The symptomatic adverse reactions produced by Caffeine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Irritability, Nausea, Vomiting, Anorexia, Anxiety, Restlessness, Tremors, Insomnia, Epigastric pain.

RISK

Drug should not be given to patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

WARNINING

Caffeine should be used with caution in diabetic patients because it may produced hyperglycemia, in anxiety disorder or panic disorder because it can aggrevate these conditions, in hepatic disease or hepatic impairment and during pregnancy and breast feeding.

STORAGE

Tab Store at room temperature. Protect from Sunlight, Moisture and Heat.

Dosage

Adult

Dose Single Frequency Route Instruction
100 to 200 mg 150 (150) As recommended. PO,IV  

Paedriatic

Dose Single Frequency Route Instruction
2.5 2.5 (2.5) As recommended. Intravenous Maintenance
10 mg/kg 10 (10) As recommended. Intravenous Load for Once
2.5 mg/kg 2.5 (2.5) As recommended. Oral Maintenance, As Required
10 mg/kg 10 (10) As recommended. Oral Load for Once

Neonatal

Dose Single Frequency Route Instruction
2.5 2.5 (2.5) As recommended. Intravenous Maintenance
10 mg/kg 10 (10) As recommended. Intravenous Load for Once
2.5 mg/kg 2.5 (2.5) As recommended. Oral Maintenance, As Required
10 mg/kg 10 (10) As recommended. Oral Load for Once

Paracetamol 1mg/ml

CHARACTERSTICS

Paracetamol also known as Acetaminophen, Acetaminophen. . It is of Synthetic origin and belongs to Aminophenol. It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents pharmacological group.The Molecular Weight of Paracetamol is 151.20. Its pKa is 9.5.

INDICATIONS

Paracetamol is primarily indicated in conditions like Ear pain, Fever, Headache, Malaise, Migraine, Mild to moderate pain, Pain, Post-vaccine reaction, Short-bowel syndrome, Tobacco amblyopia and leber's optic atrophy, Toothache.

INTERACTIONS

Paracetamol is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdefovir DipivoxilAlcoholAscorbic AcidAscorbic acid increases half life of acetaminophen.Azilisartan MedoxomilAzilisartan when administered with NSAIDS (like paracetamol) can lead to volume depletionBusulphanMetabolism of Intravenous Busulphan possibly inhibited Paracetamol (caution is advised within 72 hours of Paracetamol).Carbamazepineplasma concentration of paracetamol may be reduced by anti epileptic such as carbamazepine, phenobarbital , phenytoin or primidoneMinorChloramphenicolCimetidine (HCl)DiflunisalInterferon AlphaIsoniazidIsoniazid exacerbate the hepatotoxicity of acetaminophen by inducing its CYP450 2E1 metabolism results in toxic metabolites.ModerateCoadministration is considered contraindicated. Cmonitor the patient for hepatotoxicity. Aspirin is considered as safer alternative of paracetamol.Itopride (HCl)Metoclopramide (HCl)Probenecidpretreatment with probenecid can decrease paracetamol clearance and increase plasma half life MinorPropantheline (Br)Propantheline decreases the gastrointestinal absorption of acetaminophen by reducing gastric motility and delaying gastric emptying.MinorSulphinpyrazoneSulphinpyrazone increases the hepatotoxicity of paracetamol and decreases its pharmacological effect by accelerating the metabolism of paracetamol.ModerateUse of this combination should be avoided over a prolong period of time. Closely monior for hepatotoxicity.Warfarin (Na)Warfarin (Na)Paracetamol potentiate the hypoprothrombinemic effect of warfarinMinorMonitor signs of bleeding.ZidovudineCombined use of these agents may potentiate the risk of bone marrow suppression and hepatotoxicity.MinorClosely monitor the patient for the development hepatotoxicity and bone marrow toxicity. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

CONTRAINDICATIONS

Paracetamol is contraindicated in conditions like Hypersensitivity.

EFFECTS

The severe or irreversible adverse effects of Paracetamol, which give rise to further complications include Bronchospasm.Paracetamol produces potentially life-threatening effects which include Blood dyscrasias, Centribular Necrosis, Liver damage. which are responsible for the discontinuation of Paracetamol therapy.The signs and symptoms that are produced after the acute overdosage of Paracetamol include hypoglycemic coma, Hepatic necrosis, Liver failure, renal tubular necrosis.The symptomatic adverse reactions produced by Paracetamol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Skin rashes, GI adverse effects.

RISK

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

WARNINING

If sensitivity reaction occurs, discontinue use of paracetamol. If pain persist more than 10 days and arthritic and rheumatic condition affecting children, immediately consult physician. If patient have been diagnosed with liver or kidney impairment, seek medical advice before taking medication. If symptoms persists consult doctor.

STORAGE

tab,syr,susp Store in a well closed container, Below 40�C. Protect from Sunlight and Moisture.

Dosage

Adult

Dose Single Frequency Route Instruction
500 to 1000 mg 750 (750) 6 hourly PO Maximum adult dose is 4 g/day in divided doses (i.e. 1g every 6 hourly)

Paedriatic

Dose Single Frequency Route Instruction
10 to 15 mg/kg/dose 12 (12.5) 6 hourly Oral  

Neonatal

Dose Single Frequency Route Instruction
12 mg/kg 12 (12) 6 hourly Oral -
Description

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